Ireland have made nine changes to their side as they face Fiji in the Autumn Nations Series in Dublin on Saturday.
Head coach Andy Farrell has used this game to give an opportunity to some fringe members of the squad, despite retaining an experienced core.
World-class tighthead Tadhg Furlong is one of those to remain and is handed the captaincy responsibility.
Five alterations in the pack
Furlong joins Rob Herring and Jeremy Loughman in the front-row, who have replaced Andrew Porter and Dan Sheehan respectively.
Tadhg Beirne keeps his place at lock but Kieran Treadwell comes in for James Ryan, who is rested.
In the back-row, Caelan Doris switches to blindside flanker to allow Jack Conan to start at number eight, while the in-form Nick Timoney is handed a chance at openside.
Behind the scrum, it is a new half-back partnership as Joey Carbery is at fly-half alongside Jamison Gibson-Park, who is in for the injured Conor Murray.
Robbie Henshaw back from injury
At centre, Stuart McCloskey is fit enough to retain his place and he partners injury-returnee Robbie Henshaw in a powerful Ireland midfield combination.
Robert Baloucoune and Mack Hansen remain on the wing, with Jimmy O’Brien starting at full-back after impressing off the bench last weekend.
Ireland: 15 Jimmy O’Brien, 14 Robert Baloucoune, 13 Robbie Henshaw, 12 Stuart McCloskey, 11 Mack Hansen, 10 Joey Carbery, 9 Jamison Gibson-Park, 8 Jack Conan, 7 Nick Timoney, 6 Caelan Doris, 5 Tadhg Beirne, 4 Kieran Treadwell, 3 Tadhg Furlong (c), 2 Rob Herring, 1 Jeremy Loughman
Replacements: 16 Dan Sheehan, 17 Cian Healy, 18 Tom O’Toole, 19 Cian Prendergast, 20 Max Deegan, 21 Craig Casey, 22 Jack Crowley, 23 Garry Ringrose
Date: Saturday, November 12
Venue: Aviva Stadium, Dublin
Kick-off: 13:00 GMT
Referee: Mathieu Raynal (France)
Assistant Referees: Tual Trainini (France), Jordan Way (Australia)
TMO: Chris Hart (New Zealand)